which restaurant is your favourite?the biggest one in Fifth Street!此句中的 in Fifth Street!能否换成on Fifth Street!

which restaurant is your favourite?the biggest one in Fifth Street!此句中的 in Fifth Street!能否换成on Fifth Street!
which restaurant is your favourite?the biggest one in Fifth Street!此句中的 in Fifth Street!能否
换成on Fifth Street!

which restaurant is your favourite?the biggest one in Fifth Street!此句中的 in Fifth Street!能否换成on Fifth Street!
这个问题如果你问一个老外,他会告诉你都行.但是这个情景下,他们通常用in；如果你非要较真的问有什么区别,他会这么回答你
in 说的范围个广泛一点,在第五大道上面.
on 就更小一点,比如第五大道上和和53街的那个路口.

in是英国用法，on是美国用法。两者均可，所以可以互换。